Posts found in:
Grantees

Project Title: Therapeutic use of HDL to enhance the anti-leukemia effects of allo-HCT while preventing GvHD Project Description: Clinical goal of bone marrow transplantation (BMT) is to enhance anti-leukemia effects of BMT while preventing its major side effect, graft-versus-host disease (GvHD). We have identified gene products that are modulated by HDL, the good cholesterol, as […]

Project Title: Developing genomic biomarkers for multiple myeloma and T-cell immunotherapy from cell-free DNA Project Description: Multiple myeloma (MM) is the second most common blood cancer. While new treatments have emerged for MM in the last decade, tests to diagnose MM have not changed. We will develop ‘liquid biopsies’ to diagnose, detect, and study MM, […]

Project Title: Overcoming CAR T Resistance in Acute Myeloid Leukemia by Using Systemic Vaccination Project Description: This project aims to investigate the mechanisms by which a novel cancer vaccine enhances tumor rejection caused by genetically modified immune cells against acute myeloid leukemia. Genetically engineered immune cells have not yet shown great promise against this specific […]

Project Title: Recipient specific CAR-T cells for AML relapse after allogeneic hematopoietic stem cell transplantation Project Description: Bone marrow transplants are the best treatment for some leukemia patients, but there are few good treatments for leukemia that relapses after transplant. In this project, we exploit genetic differences between patients and their donors to make immune […]

Project Title: Chemical genetic dissection of oncoenhancers in multiple myeloma Project Description: Multiple myeloma is caused by faulty activation of growth genes. Our research aims to develop new therapeutics that target the factors driving this malfunctioning expression. The support of Gabrielle’s Angel Foundation will enable us to develop tools to study the myeloma epigenome and […]

Project Title: A multiomic dissection of clonal evolution in MDS Project Description: Our research will serve to identify patterns of “clonal evolution”, wherein multiple distinct populations of similar cells, called subclones, gain or lose prominence as they react to the treatment given. This project will allow us to leukemia cell “family trees” in a patient […]

Project Title: New principles for designing chimeric antigen receptors Project description: CAR-T cells represent a revolutionary tool for targeted treatment of leukemias and lymphomas. However, the mechanisms by which these cells attack tumor remains unclear. Our project aims to clarify and leverage the biophysical properties of CAR-T cell signaling to improve treatment of blood cancers.

Title of Grant:       Engineered Natural Killer Cell Therapies Targeting Acute Myeloid Leukemia Description: Acute myeloid leukemia (AML) is a highly prevalent form of blood cancer with extremely low survival rates. Therapies that activate the patient’s immune system to fight disease have been successful in many leukemias, but not AML. We will create a new immune-activating […]

Title of Grant: Dietary Serine Modulation as a Precision Nutrition Therapy for AML Description: Integrative cancer treatments incorporating diet are needed. We have found that certain patients with acute myeloid leukemia may benefit from a dietary intervention affecting the amino acid serine. We propose studies to better understanding and improve upon this intervention so that […]

Fox Chase Cancer Center Title of Grant: Investigating the essential roles of Kelch-like family member KLHL11 in the pathogenesis of Anaplastic Large Cell Lymphoma and in normal T cells Description:          This project will seek to address the importance of a novel E3 ligase, KLHL11, in the pathogenesis of T cell lymphoma and in normal T […]

Title of Grant:       Role of co-stimulatory domains in CAR T cell dysfunction Description: Cell-based immune therapies have demonstrated impressive success in the treatment of blood cancers, however most patients treated with available cellular immunotherapies are not cured. The goal of this proposal is to identify the molecular pathways responsible for failure of these therapies and […]

Title of Grant:       Dissecting the role of the unfolded protein response in type 1 CALRmutated myelofibrosis  Description: The experiments proposed will help to answer why, among the two types of CALR mutations found in MPN patients, only one type causes myelofibrosis, the most deadly and difficult to treat disease among the three MPN types. This […]