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The Role of AML/1ETO in the Pathogenesis of t(8;21) Acute Myeloid Leukemia This year, approximately 10,500 adults will be diagnosed with acute myeloid leukemia (AML) in the U.S. Despite incremental improvements in the care of these patients over the past three decades, most will die of their disease. My laboratory is studying the AML subtype […]

The Memorial Sloan-Kettering Cancer Center’s Integrative Medicine Service’s Music Therapy Program brings music to the bedside of hundreds of patients by trained, credentialed professionals who tailor their offerings to the needs of individuals and their family members. This vital service is offered to both patients and their families providing therapists who work closely as part […]

Splicing and Epigenetic Control of Hematopoiesis in MDS and Leukemia The discovery of new cancer mutations brings the reality of targeted therapy into reach; if we can understand how the mutations work and which other factors are involved. Our research will address these questions and lead to new therapies that will selectively kill mutant cells […]

miR-23a Cluster and miR-10a Regulation of Self-Renewal and Survival Pathways in Human Hematopoietic Stem-Progenitor Cells and Acute Leukemia Cells The goals of this project are to investigate the regulation of genes and pathways involved in self-renewal and survival pathway in leukemia stem cells (LSCs) by small molecules called microRNA. Two of these microRNAs, the mir-23a […]

Defining the role of the inv(16)-encoded CBFA2T3-GLIS2 chimeric transcription factor in the pathogenesis of pediatric acute megakaryoblastic leukemia We have identified a mutation that fuses two genes together resulting in an aberrant protein, CBFA2T3-GLIS2, in ~1/3 of pediatric acute megakaryoblastic leukemia patients. We have demonstrated that this protein enhances the cell’s ability to self-renew. Our […]

Identification of microRNAs that can inhibit T-cell acute lymphoblastic leukemia (T-ALL) cell survival and proliferation Leukemia cells exhibit altered growth requirements. Using a functional screening approach, we will identify microRNAs that inhibit growth of T-ALL cell lines as a method to discern which microRNAs have potential therapeutic value. Analysis of microRNA targets will elucidate intracellular […]

Modulation of Estrogen Metabolites by Broccoli Sprouts: Novel Intermediate Markers for Chemoprevention In the last decade the prevention of cancer through the use of chemopreventive agents has become a possibility. We are now faced with how best to begin to assess the effectiveness of potential agents for a variety of cancer sites. With this in […]

Interrupting Survival Signals in Early Stage CLL: A Maneuver to Prevent Progression Chronic Lymphocytic leukemia (CLL) is the most common sub-type of leukemia in the U.S. and is presently an incurable disease. Building on his preclinical and clinical observations, Dr. Shanafelt has opened a clinical trial of green tea extract in capsule form for patients […]

Cleaved Serpins as Anti-Angiogenic Therapeutics in the Treatment of Cancer Angiogenesis-the formation of new blood vessels-is critical to the growth and survival of many tumors, and occurs at a much accelerated pace in tumors compared to normal tissue. Angiogenesis inhibitors, investigational agents that starve out tumors by cutting off their blood supply, hold out great […]

Overcoming L-Asparaginase Resistance Caused by Adipocyte Production of Glutamine Overweight leukemia patients are harder to cure than thin patients. We found that an important chemotherapy, L-asparaginase, does not work as well in overweight mice compared to thin mice. Fat cells produce glutamine, which we think may help leukemia cells resist this important medicine. We will […]

Double Unit Grafts for the Treatment of High Risk Hematologic Malignancies Umbilical cord blood (UCB) collected from healthy newborns is an alternative source of blood-forming stem cells and UCB transplant is a very promising treatment strategy in children with leukemia. However, early experience in UCB transplant in adults has not been successful in many patients […]

Functional and Genetic Analysis of a Novel RB-Associated Transcriptional Repressor in Human Leukemia and Lymphoma Researchers have identified and studied a gene known as the RB gene that acts as a natural tumor suppressor by regulating cell proliferation (multiplication of cells). Abnormal cell proliferation is one characteristic of cancer, and the inability to “turn off” […]