Dr. Aaron Viny, MD, MS

Investigating chromatin biomarkers for therapeutic sensitivity to Menin inhibition in myeloid malignancies

Cellular DNA is structured as “open” or “closed” chromatin fibers which influences whether genes can be activated/de-activated. Chromatin structure is markedly perturbed in myelodysplastic syndrome and acute myeloid leukemia. This translational proposal tests the hypothesis that “open-ness” of MEIS1 target genes is a biomarker of clinical sensitivity to Menin inhibition.