Franco Izzo, PHD

Clonal Evolution and Epigenetic Plasticity drive Resistance to Hypomethylating Agents in Myelodysplastic Syndrome

The proposed project explores why some Myelodysplastic Syndrome (MDS) patients become resistant to a common treatment. By studying genetic and epigenetic changes in single cells from patients, we aim to uncover the mechanisms driving this resistance. Our findings could lead to better treatment strategies and improved outcomes for MDS patients.