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The role of miR-126 in core-binding factor acute myeloid leukemia Acute myeloid leukemia (AML), one of the most common types of leukemia, is a cancer of blood cells that originate in the bone marrow. Two common subtypes of AMLs are associated with chromosome rearrangements, such as translocations between chromosome 8 and 21 or inversions within […]

Killing Two Birds with One Stone: Dual Modal Gene Therapy for Leukemia Using Chimeric Nanoparticles Genetic mutations in cancer cells reduce activity of molecules that cause cell death, leading to imbalanced cellular signals and prolonged leukemia cell survival. This project aims to genetically re-balance the molecular signals toward programmed death in leukemia cells. We will […]

Therapeutic effect of Boswellia Carterri Birdw in Acute Myelocyctic Leukemia Traditional Chinese Medicine is a potential source for modern cancer therapies but western technology and clinical trials are required properly to identify, understand, and evaluate the active components. This is best exemplified by the dramatic clinical responses to all trans retinoic acid and arsenic trioxide […]

Targeting Slit2/Robo4 Signaling as a Novel Treatment for Leukemia Slit2/Robo4 signaling modulates localization of hematopoietic stem cells to bone marrow (BM) vascular niches (VN), which are also involved in the pathogenesis of acute myeloid leukemia (AML). Using a BMVN model, we will examine the effects of Slit2/Robo4

Development of drugs that downregulate microRNAs associated with drug resistance A key issue in the treatment of acute leukemias, as well as other cancers is the development of resistance. Recently a small set of microRNAs (miRs) including miR-125b were found to be associated with drug resistance in acute lymphoblastic leukemia patients. In this proposal, Dr. […]

T-Cell Gene Transfer and Therapy by the Sleeping Beauty Transposon System The objective of this application is to test whether a novel, naked DNA based vehicle, Sleeping Beauty transposon, can express therapeutic molecules in human T cells for the treatment of leukemia and lymphoma. The rationale for the proposed research is based on Dr. Zhou’s […]

The Function and Regulatory Mechanism of miR-495 in Acute Myeloid Leukemia (AML) MLL-rearranged leukemia, accounting for approximately 10% of human acute leukemias, is often associated with poor prognosis.MicroRNAs (miRNAs) are a class of small RNAs mediating gene silencing. I found that miR-495 was significantly down-regulated in most AML cases with MLL rearrangements. It dramatically inhibited […]

Complementary Approaches for Treating Acute Lymphoblastic Leukemia (ALL): A Mouse ALL The aim of this project is to develop and employ complimentary and alternative approaches for treating pediatric ALL (Acute Lymphoblastic Leukemia patients). However, prior to testing such approaches in pediatric patients, potential therapies should be tested in animal models. In recent years, several good […]

Hedgehog signaling as a stem cell based therapeutic target in myelodysplastic syndrome and acute myeloid leukemia. In many ways the growth of cancer mirrors the formation of normal organs during embryonic development. Dr. Matsui has found that a specific pathway required during development called the Hedgehog signaling pathway is abnormally turned on in acute myeloid […]

Targeting leukemic stem cells in infant leukemia by blocking interactions with the microenvironment While childhood acute lymphoblastic leukemia is very curable, leukemia in infants less than six months of age is very difficult to cure. Better approaches to treatment targeting leukemia cells and leaving normal cells alone are highly desirable for these tiny patients. Dr. […]

T cells to Enhance Umbilical Cord Blood Transplantation Umbilical cord blood transplantation is potentially life-saving for patients with otherwise incurable leukemia and lymphoma, but is still limited by delayed recovery of normal blood cells, risk of infections and the risk of disease returning. My research focuses on understanding, employing and activating T cells to address […]

A Pilot Study Evaluating the Microbiome and Obesity in Pediatric Acute Lymphoblastic Leukemia Pediatric ALL is a risk factor for the development of obesity. Children who develop obesity have reduced survival and increased side-effects. The intestinal microbiota has a role in the development and treatment of obesity. We propose to evaluate the intestinal microbiota so […]