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Grantees

Sarah Tasian, MD

Sarah Tasian, MD

Published: May 7, 2018   |   Author: Jason Butler   |   No Comments

Dr. Tasian is researching FLT3 Receptor-Redirected Chimeric Antigen Receptor T Call Immunotherapy for High Risk Pediatric Leukemias. Many children with high risk acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML) are resistant to chemotherapy and will relapse. We are testing new “killer T cell” immunotherapies in specialized leukemia mouse models with the goal of […]

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Siddhartha Mukherjee, MD, PhD

Siddhartha Mukherjee, MD, PhD

Published: May 7, 2018   |   Author: Jason Butler   |   No Comments

DR. Mukherjee has been dissecting the roles of Yes-1, MIIt3 and Ctnnd1 in leukemia stem cell quiescence. Hematopoietic stem cells are maintained in deep quiescence in the bone marrow. A fundamental feature of leukemias is the disruption of this quiescence, resulting in unchecked proliferation. Our laboratory has used a novel high-throughput screen to identify 3 […]

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