Xuefeng Zhang, MD, PhD

Targeting Slit2/Robo4 Signaling as a Novel Treatment for Leukemia

Slit2/Robo4 signaling modulates localization of hematopoietic stem cells to bone marrow (BM) vascular niches (VN), which are also involved in the pathogenesis of acute myeloid leukemia (AML). Using a BMVN model, we will examine the effects of Slit2/Robo4