Tami Kingsbury, PhD

Identification of microRNAs that can inhibit T-cell acute lymphoblastic leukemia (T-ALL) cell survival and proliferation

Leukemia cells exhibit altered growth requirements. Using a functional screening approach, we will identify microRNAs that inhibit growth of T-ALL cell lines as a method to discern which microRNAs have potential therapeutic value. Analysis of microRNA targets will elucidate intracellular signaling pathways critical for T-ALL cell survival and proliferation.