Shan Zha, MD, PhD

The role of ATM kinase in suppression of B cell lymphomas

Our lab is interested in understanding how cells sense DNA double stand breaks, integrate cell cycle progression and cellular survival to facilitate precise DNA repair and to prevent cancer-causing transformation. Defects in DNA repair machinery often lead to primary immunodeficiency and increase the risk for lymphomas and leukemias in children. In this context, we generate and characterize mouse models to study the mechanism of DNA repair and lymphomagenesis.