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Identification of microRNAs that can inhibit T-cell acute lymphoblastic leukemia (T-ALL) cell survival and proliferation Leukemia cells exhibit altered growth requirements. Using a functional screening approach, we will identify microRNAs that inhibit growth of T-ALL cell lines as a method to discern which microRNAs have potential therapeutic value. Analysis of microRNA targets will elucidate intracellular […]

Modulation of Estrogen Metabolites by Broccoli Sprouts: Novel Intermediate Markers for Chemoprevention In the last decade the prevention of cancer through the use of chemopreventive agents has become a possibility. We are now faced with how best to begin to assess the effectiveness of potential agents for a variety of cancer sites. With this in […]

Interrupting Survival Signals in Early Stage CLL: A Maneuver to Prevent Progression Chronic Lymphocytic leukemia (CLL) is the most common sub-type of leukemia in the U.S. and is presently an incurable disease. Building on his preclinical and clinical observations, Dr. Shanafelt has opened a clinical trial of green tea extract in capsule form for patients […]

Cleaved Serpins as Anti-Angiogenic Therapeutics in the Treatment of Cancer Angiogenesis-the formation of new blood vessels-is critical to the growth and survival of many tumors, and occurs at a much accelerated pace in tumors compared to normal tissue. Angiogenesis inhibitors, investigational agents that starve out tumors by cutting off their blood supply, hold out great […]

Overcoming L-Asparaginase Resistance Caused by Adipocyte Production of Glutamine Overweight leukemia patients are harder to cure than thin patients. We found that an important chemotherapy, L-asparaginase, does not work as well in overweight mice compared to thin mice. Fat cells produce glutamine, which we think may help leukemia cells resist this important medicine. We will […]

Double Unit Grafts for the Treatment of High Risk Hematologic Malignancies Umbilical cord blood (UCB) collected from healthy newborns is an alternative source of blood-forming stem cells and UCB transplant is a very promising treatment strategy in children with leukemia. However, early experience in UCB transplant in adults has not been successful in many patients […]

Functional and Genetic Analysis of a Novel RB-Associated Transcriptional Repressor in Human Leukemia and Lymphoma Researchers have identified and studied a gene known as the RB gene that acts as a natural tumor suppressor by regulating cell proliferation (multiplication of cells). Abnormal cell proliferation is one characteristic of cancer, and the inability to “turn off” […]

A Pilot Study of Investigating the Effects of Glutamine and Vincristine-induced Neuropathy in Pediatric Patients with Cancer Patients with cancer are amongst the highest users of complementary/alternative therapies. Recent surveys have found 84% of pediatric oncology patients on standard anticancer protocols are taking some form of complementary/alternative medicine. However the safety of these therapies combined […]

Reproductive and sexual concerns of young women treated for lymphoma, leukemia and breast cancer Dr. Goldfarb’s team will document the impact of cancer treatment on reproductive and sexual health in young women treated for lymphoma, leukemia and breast cancer.  Premature ovarian failure and sexual dysfunction are serious problems that reduce their quality of life.  They […]

Genomics of Peripheral T-Cell Lymphoma Peripheral T-cell lymphoma (PTCL) is a group of rare diseases that collectively comprise 15 percent of lymphomas. The diseases are poorly understood and often have poor prognosis. Memorial Sloan-Kettering Cancer Center has one of the highest volumes of PTCL patients the country. This provides opportunity to study the disease by […]

The role of ATM kinase in suppression of B cell lymphomas Our lab is interested in understanding how cells sense DNA double stand breaks, integrate cell cycle progression and cellular survival to facilitate precise DNA repair and to prevent cancer-causing transformation. Defects in DNA repair machinery often lead to primary immunodeficiency and increase the risk […]

Epigenetic Programs in MLL-rearranged leukemias The Armstrong lab is using high throughput approaches that assess gene activity and chromosome structure in leukemias. Recent data suggest that certain mutations induce acute myelogenous leukemia (AML) by altering chromosome structure. The proteins that control the abnormal chromatin structure in these leukemias are enzymes (called histone methyltransferases) that present […]