Medical Updates

NIH initiative to systematically investigate and establish function of every human gene

NIH initiative to systematically investigate and establish function of every human gene

Published: Sep 29, 2022   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

The National Institutes of Health is launching a program to better understand the function of every human gene and generate a catalog of the molecular and cellular consequences of inactivating each gene. The Molecular Phenotypes of Null Alleles in Cells (MorPhiC) program, managed by the National Human Genome Research Institute, aims to systematically investigate the […]

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New Grantees Announced

New Grantees Announced

Published: Sep 29, 2022   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

In June, Gabrielle’s Angel Foundation’s Medical Advisory Board selected 16 talented early career scientists to receive funding for a total of $1.8M in grants! Awards ranged from $25,000 – $225,000. We are delighted to welcome these brilliant investigators to our Gabrielle’s Angels family! Stay tuned for spotlights on each grantee and their work throughout the rest of the year. ** Special […]

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Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs

Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs

Published: Sep 20, 2022   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

Congratulations to Gabrielle’s Angels grantees Dr. Ann Mullally and Dr. Shannon Elf for their recent publication in September’s issue of Blood.  Read the full paper here: “Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs”  Abstract Calreticulin (CALR) mutations are frequent, disease-initiating events in myeloproliferative neoplasms (MPNs). Although the biological mechanism by […]

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Preventing ‘chemo brain’ with antioxidants targeting spinal fluid

Preventing ‘chemo brain’ with antioxidants targeting spinal fluid

Published: Sep 15, 2022   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

Up to three quarters of patients receiving cancer chemotherapy suffer from “chemo brain” — a long-term side effect that makes it harder to remember things, maintain attention, and learn new information. When it strikes children, whose brains are still developing, their schoolwork and self-esteem may suffer. In a study published in the journal Neuron on September […]

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11th Annual Medical Research Symposium

11th Annual Medical Research Symposium

Published: Jun 7, 2022   |   Author: Michele Keene   |   Category: Medical Updates, What's New   |   No Comments

  On May 24th, 2022 we hosted our 11th annual Medical Research Symposium at Feinstein’s/54 Below in New York City. We hosted researchers both past and present…some we funded as far back as 2000 and some as recently as 2021! It was a wonderful day of presentations, networking, and collaboration. Thank you to our sponsor […]

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Scientists uncover a new approach for treating aggressive cancer

Scientists uncover a new approach for treating aggressive cancer

Published: Feb 28, 2022   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

Researchers at the University of North Carolina at Chapel Hill and the UNC Lineberger Comprehensive Cancer Center have uncovered a new role of a chromatin-modulatory enzyme, termed EZH2, during cancer development. They then developed a new therapeutic approach with a potent small-molecule inhibitor of this enzyme. Gabrielle’s Angels supported this work with a grant to […]

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Dr. Shan Zha elected to the American Society for Clinical Investigation

Dr. Shan Zha elected to the American Society for Clinical Investigation

Published: Feb 16, 2022   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

Congratulations to Gabrielle’s Angel Foundation grantee Dr. Shan Zha for being elected to the American Society for Clinical Investigation. “Shan’s work is simply inspiring and is transforming the understanding of DNA repair and how we might utilize that understanding to develop new therapies,” says Jordan Orange, MD, PhD, the Reuben S. Carpentier Professor of Pediatrics and chair of the […]

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Lymphoma cell metabolism may provide new cancer target

Lymphoma cell metabolism may provide new cancer target

Published: Jan 6, 2022   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

Gabrielle’s Angels grantee Dr. Ari Melnick of Weill Cornell and his team have recently discovered that aggressive and relatively common lymphomas called diffuse large B cell lymphomas have a critical metabolic vulnerability that can be exploited to trick these cancers into starving themselves. This is a huge breakthrough with many possibilities for future therapeutic applications!  […]

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For children, young adults with recurrent AML, immunotherapy shows promise

For children, young adults with recurrent AML, immunotherapy shows promise

Published: Dec 15, 2021   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

An immunotherapy harnessing the immune system’s “natural killer” cells has proven effective in treating acute myeloid leukemia (AML) in some adults whose cancers return. Now, researchers at Washington University School of Medicine in St. Louis have shown, in a small clinical trial, that the same natural killer cells also can help some children and young […]

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Announcing our newest class of grantees

Announcing our newest class of grantees

Published: Nov 18, 2021   |   Author: Michele Keene   |   Category: Medical Updates, What's New   |   No Comments

Clockwise from top left: Andrew Intlekofer, MSKCC; Shannon Elf*, University of Chicago, Nathan Singh, Washington University St. Louis; Yibin Yang*, Fox Chase Cancer Center; Brian Dalton, Johns Hopkins University; Jamie Berta Spangler; Johns Hopkins University *Mark Foundation for Cancer Research Fellows – these grants will be fully funded by the Mark Foundation The Foundation’s Medical […]

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New technique may lead to safer stem cell transplants

New technique may lead to safer stem cell transplants

Published: Nov 18, 2021   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

A new study from the lab of longtime Gabrielle’s Angel Foundation Medical Advisory Board member Dr. John DiPersio and Gabrielle’s Angels grantee Dr. Stephen Persaud has revealed a new technique that may lead to safer stem cell transplants. The researchers at Washington University School of Medicine in St. Louis have developed a method of stem […]

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