Medical Updates

Gabrielle’s Angels Grantee Dr. Cigall Kadoch Receives Prestigious Howard Hughes Medical Institute (HHMI) Investigators Award

Gabrielle’s Angels Grantee Dr. Cigall Kadoch Receives Prestigious Howard Hughes Medical Institute (HHMI) Investigators Award

Published: Sep 29, 2021   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

Congratulations to Gabrielle’s Angels grantee Dr. Cigall Kadoch from Dana-Farber Cancer Institute for receiving the incredibly prestigious Howard Hughes Medical Institute (HHMI) Investigators Award! Dr. Kadoch will receive roughly $9 million over a seven-year term, which is renewable pending a successful scientific review. HHMI selected the new Investigators from more than 800 eligible applicants. To […]

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Announcing our partnership with the Mark Foundation for Cancer Research

Announcing our partnership with the Mark Foundation for Cancer Research

Published: Sep 7, 2021   |   Author: Michele Keene   |   Category: Medical Updates, What's New   |   No Comments

The Mark Foundation for Cancer Research has partnered with the Gabrielle’s Angel Foundation for Cancer Research to fully support two of its Medical Research Awardees. The awardees, Dr. Shannon Elf from the University of Chicago, and Dr. Yibin Yang from Fox Chase Cancer Center were announced at the Angel Foundation’s 25th Angel Ball on August […]

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Can AML be prevented?

Can AML be prevented?

Published: Jul 14, 2021   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

Big news from the lab of former Gabrielle’s Angels grantee Dr. Scott Armstrong and his colleagues at Dana Farber! A new drug that not only could treat acute myeloid leukemia but also potentially prevent the cancer from developing is now being evaluated in clinical trials. This drug, SNDX-5613, successfully reversed leukemia development in mice and […]

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Dr. Esther Obeng: At Home in Her Lab at St. Jude

Dr. Esther Obeng: At Home in Her Lab at St. Jude

Published: May 14, 2021   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

We love this feature on one of our fabulous grantees, Dr. Esther Obeng of St. Jude! Not only is Dr. Obeng a first-generation American, she’s also designing studies to identify cancer-causing mutations and then developing clinical trials with revolutionary therapies that target them. “One of the reasons that I study the research that I do […]

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Scientists develop new CRISPR-based tool to control epigenome

Scientists develop new CRISPR-based tool to control epigenome

Published: Apr 27, 2021   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

Scientists have revealed how to modify CRISPR’s basic architecture to extend its reach beyond the genome and into the epigenome – proteins and small molecules that latch onto DNA and control when and where genes are switched on or off. Researchers at University of California San Francisco (UCSF) and the Whitehead Institute, both US, developed the […]

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Less is more for the next generation of CAR T cells

Less is more for the next generation of CAR T cells

Published: Apr 23, 2021   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

When researchers from Penn Medicine (including two of our grantees, Dr. Saar Gill and Dr. Marco Ruella!) found that many patients with B-cell acute lymphoblastic leukemia (ALL) treated with the investigational chimeric antigen receptor (CAR) T cell therapy targeting the CD22 antigen didn’t respond, they went back to the drawing board to determine why. They […]

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She’s Beating Leukemia With a Healthy Change to Her Diet

She’s Beating Leukemia With a Healthy Change to Her Diet

Published: Apr 8, 2021   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

More details about the study from Gabrielle’s Angels grantee Dr. Etan Orgel! The study found that kids who ate healthier, slightly cut their calorie intake, and burned a bit more energy through exercise wound up with a lot fewer cancer cells lingering in their bodies following their first month of chemo, compared with an earlier […]

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Diet and exercise may increase efficacy of chemotherapy for children with cancer

Diet and exercise may increase efficacy of chemotherapy for children with cancer

Published: Apr 2, 2021   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

(left: Dr. Steven Mittelman, right: Dr. Etan Orgel) New research published today in the journal Blood Advances is the first to show that restricting calories, reducing fat and sugar intake, and increasing physical activity may boost the effectiveness of chemotherapy for older children and adolescents with leukemia. This intervention, which improved chemotherapy outcomes for children […]

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Study finds cancer cells may evade chemotherapy by going dormant

Study finds cancer cells may evade chemotherapy by going dormant

Published: Mar 15, 2021   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

Cancer cells can dodge chemotherapy by entering a state that bears similarity to certain kinds of senescence, a type of “active hibernation” that enables them to weather the stress induced by aggressive treatments aimed at destroying them, according to a new study by scientists at Weill Cornell Medicine (including Dr. Ari Melnick, former Gabrielle’s Angels […]

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CRISPR-edited CAR T Cells Enhance Fight Against Blood Cancers

CRISPR-edited CAR T Cells Enhance Fight Against Blood Cancers

Published: Mar 11, 2021   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

Congratulations to Gabrielle’s Angels grantee Dr. Marco Ruella and his colleagues at the Perelman School of Medicine University of Pennsylvania on this impressive breakthrough! Dr. Ruella and his team discovered that knocking out a protein known to stifle T cell activation on CAR T cells using the CRISPR/Cas9 technology enhanced the engineered T cells’ ability […]

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Yale Study Connects Long COVID with Autoantibodies

Yale Study Connects Long COVID with Autoantibodies

Published: Mar 11, 2021   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

Our researchers are not only making an impact in blood cancer research, they’re also making important discoveries in the fight against Covid. Immunologists Akiko Iwasaki, PhD, and Gabrielle’s Angels grantee Aaron Ring, MD, PhD, have identified autoantibodies in patients who have had COVID-19. Autoantibodies are antibodies (proteins produced in response to a pathogen) that mistakenly […]

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Rogue antibodies could be driving severe COVID-19

Rogue antibodies could be driving severe COVID-19

Published: Mar 11, 2021   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

More details about the important work that one of our grantees, Dr. Aaron Ring at Yale University, has been contributing to throughout the pandemic. He has been focused on discovering answers to questions like why do some people get so much sicker than others? What is behind the extended, multi-organ illness that lasts for months […]

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