Medical Updates

A study from Washington University School of Medicine in St. Louis suggests a strategy for preventing a chronic, slow-growing type of blood cancer from progressing to an aggressive form of leukemia.  A type of chronic leukemia can simmer for many years. Some patients may need treatment to manage this type of blood cancer — called […]

The National Institutes of Health is launching a program to better understand the function of every human gene and generate a catalog of the molecular and cellular consequences of inactivating each gene. The Molecular Phenotypes of Null Alleles in Cells (MorPhiC) program, managed by the National Human Genome Research Institute, aims to systematically investigate the […]

In June, Gabrielle’s Angel Foundation’s Medical Advisory Board selected 16 talented early career scientists to receive funding for a total of $1.8M in grants! Awards ranged from $25,000 – $225,000. We are delighted to welcome these brilliant investigators to our Gabrielle’s Angels family! Stay tuned for spotlights on each grantee and their work throughout the rest of the year. ** Special […]

Congratulations to Gabrielle’s Angels grantees Dr. Ann Mullally and Dr. Shannon Elf for their recent publication in September’s issue of Blood.  Read the full paper here: “Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs”  Abstract Calreticulin (CALR) mutations are frequent, disease-initiating events in myeloproliferative neoplasms (MPNs). Although the biological mechanism by […]

Up to three quarters of patients receiving cancer chemotherapy suffer from “chemo brain” — a long-term side effect that makes it harder to remember things, maintain attention, and learn new information. When it strikes children, whose brains are still developing, their schoolwork and self-esteem may suffer. In a study published in the journal Neuron on September […]

Acute myeloid leukemia, or AML, is the most common acute blood cancer in adults — and one of the most difficult to treat. Scientists at Oregon Health & Science University have discovered a potential new target for stopping it: a gene that, when active, predicts worse chances of survival.

  On May 24th, 2022 we hosted our 11th annual Medical Research Symposium at Feinstein’s/54 Below in New York City. We hosted researchers both past and present…some we funded as far back as 2000 and some as recently as 2021! It was a wonderful day of presentations, networking, and collaboration. Thank you to our sponsor […]

Researchers at the University of North Carolina at Chapel Hill and the UNC Lineberger Comprehensive Cancer Center have uncovered a new role of a chromatin-modulatory enzyme, termed EZH2, during cancer development. They then developed a new therapeutic approach with a potent small-molecule inhibitor of this enzyme. Gabrielle’s Angels supported this work with a grant to […]

Congratulations to Gabrielle’s Angel Foundation grantee Dr. Shan Zha for being elected to the American Society for Clinical Investigation. “Shan’s work is simply inspiring and is transforming the understanding of DNA repair and how we might utilize that understanding to develop new therapies,” says Jordan Orange, MD, PhD, the Reuben S. Carpentier Professor of Pediatrics and chair of the […]

Gabrielle’s Angels grantee Dr. Ari Melnick of Weill Cornell and his team have recently discovered that aggressive and relatively common lymphomas called diffuse large B cell lymphomas have a critical metabolic vulnerability that can be exploited to trick these cancers into starving themselves. This is a huge breakthrough with many possibilities for future therapeutic applications!  […]

An immunotherapy harnessing the immune system’s “natural killer” cells has proven effective in treating acute myeloid leukemia (AML) in some adults whose cancers return. Now, researchers at Washington University School of Medicine in St. Louis have shown, in a small clinical trial, that the same natural killer cells also can help some children and young […]

Clockwise from top left: Andrew Intlekofer, MSKCC; Shannon Elf*, University of Chicago, Nathan Singh, Washington University St. Louis; Yibin Yang*, Fox Chase Cancer Center; Brian Dalton, Johns Hopkins University; Jamie Berta Spangler; Johns Hopkins University *Mark Foundation for Cancer Research Fellows – these grants will be fully funded by the Mark Foundation The Foundation’s Medical […]