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Grantees

Ana Cvejic

Ana Cvejic

Published: Jun 13, 2018   |   Author: Jen Ranieri   |   No Comments

Closing the Knowledge Gap in Post-genomic Research: Fast-track Functional Characterisation of Genes Implicated in Human Blood Formation and Pathologies Using Zebrafish as an in vivo Model Dr. Ana Cvejic is hunting down genes involved in the development of leukaemia, by studying zebrafish. The processes taking place in zebrafish cells are remarkably similar to those in […]

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Adam Mead

Adam Mead

Published: Jun 13, 2018   |   Author: Jen Ranieri   |   No Comments

Unravelling Clonal Complexity in Myelofibrosis Stem Cells Though [sic] Application of Single Cell Transcriptomics Not all blood cancer cells can cause disease relapse following treatment. Understanding the biology relapse-causing “cancer stem cells” is critical, but is akin to “finding a needle in a haystack.” This grant will support the development of single-cell genetics to better […]

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Wei Tong, PhD

Wei Tong, PhD

Published: Jun 13, 2018   |   Author: Michele Keene   |   No Comments

Cytokine Signaling in Normal and Malignant Hematopoietic Stem/Progenitor Cells Dysregulation of signaling pathways that control hematopoietic stem cell expansion leads to leukemia. We aim to investigate novel signaling molecules for their roles in regulating stem cell expansion in normal and malignant blood development. Our studies may provide new insights into strategies to treat malignant and […]

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Wei Chen, MD, PhD

Wei Chen, MD, PhD

Published: Jun 13, 2018   |   Author: Michele Keene   |   No Comments

Immunotherapy of Leukemia with Dendritic Cell-Tumor Hybrid Vaccines This research project will develop a new type of human leukemia vaccine using a novel electrofusion technology. Leukemia cells will be fused with the cells that regulate body immune system function to form a hybrid cell. The hybrid cells will carry tumor-derived information (proteins) to activate the […]

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Vu Nguyen, MD

Vu Nguyen, MD

Published: Jun 13, 2018   |   Author: Michele Keene   |   No Comments

Tissue-specific immunity to preserve the graft-versus-tumor effect following hematopoietic cell transplantation Hematopoietic stem cell transplantation (HCT) can cure hematological cancers, but its wider use is limited by the high morbidity and mortality associated with graft-versus-host disease (GVHD). Current therapies for GVHD lead to nonspecific suppression or depletion of T cells, thus potentially compromising the ability […]

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Lukas D. Wartman, MD

Lukas D. Wartman, MD

Published: Jun 13, 2018   |   Author: Jen Ranieri   |   No Comments

Integrative Epigenomics: The Consequences of Kdm6a Inactivation on Chromatin Accessibility and DNA Methylation in Hematopoiesis We will determine if mutations in the gene, KDM6A, which are present in a wide variety of human cancers, are also associated with specific modifications of DNA (DNA methylation) and DNA structure. These associated changes may explain how KDM6A mutations […]

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Vu Ngo, PhD

Vu Ngo, PhD

Published: Jun 13, 2018   |   Author: Michele Keene   |   No Comments

Targeting Cyclin D1 and the DNA Damage Response in Mantle Cell Lymphoma Mantle cell lymphoma (MCL) is rarely curable. Its hallmark is overexpression of the cell cycle regulatory protein cyclin-D1. We uncovered an unexpected role of cyclin-D1 in maintaining MCL genome integrity. We will investigate whether targeting cyclin-D1 simultaneously with proteins that guard against DNA […]

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Louie Naumovski, MD

Louie Naumovski, MD

Published: Jun 13, 2018   |   Author: Jen Ranieri   |   No Comments

Chemo Resistance to Phase I/II Anti-cancer Agents One of the key limitations of chemotherapy is the development of tumor cells that are resistant to various known chemotherapy drugs. In patients with leukemia or lymphoma who relapse following primary chemotherapy, it is common to try new anti-cancer drugs, many of them in early clinical trials (Phase […]

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Ulrich Steidl, MD, PhD

Ulrich Steidl, MD, PhD

Published: Jun 13, 2018   |   Author: Michele Keene   |   No Comments

Identification of Functionally Critical Transcriptional Target Genes in Stem Cells in AML & MDS Despite the use polychemotherapies which reduce the tumor burden, relapse continues to be the most common cause of death in myelodysplastic syndromes (MDS) and acute myeloid leukemias (AML). Recent evidence demonstrates that rare so-called leukemia stem cells (LSC) give rise to […]

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Todd Fehniger, MD, PhD

Todd Fehniger, MD, PhD

Published: Jun 13, 2018   |   Author: Michele Keene   |   No Comments

Cytokine-Induced Memory-Like NK Cells For Adoptive Immunotherapy of AML. Recent scientific advances have shown that cytokine activation results in cytokine-induced memory-like (CIML) NK cells with superior anti-leukemia activity. We will translate CIML NK cells into a first-in-human clinical trial for acute myeloid leukemia patients. Correlative studies will evaluate CIML NK cells expansion, survival, activation, and […]

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Kirsten Ness, PT, PhD

Kirsten Ness, PT, PhD

Published: Jun 13, 2018   |   Author: Jen Ranieri   |   No Comments

Vibration Intervention for Bone Enhancement in Childhood Cancer Survivors Interventions to improve Bone Marrow Density (BMD), and prevent early onset osteoporosis and fracture are essential to promote long, productive lives, free from persistent pain and/or disability. Current treatments for BMD decrements among childhood cancer survivors are limited to those who can tolerate a pharmacologic agent, […]

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Timothy Graubert, MD

Timothy Graubert, MD

Published: Jun 13, 2018   |   Author: Michele Keene   |   No Comments

The Role of AML/1ETO in the Pathogenesis of t(8;21) Acute Myeloid Leukemia This year, approximately 10,500 adults will be diagnosed with acute myeloid leukemia (AML) in the U.S. Despite incremental improvements in the care of these patients over the past three decades, most will die of their disease. My laboratory is studying the AML subtype […]

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