Katrin Ottersbach, PhD

Development and Characterisation of a Mouse Model for Infant Leukaemia

Infants with leukaemia caused by the MLL-AF4 mutation have a poor prognosis. MLL-AF4 alone failed to incite leukaemia in mouse models, impeding research into therapies. We will introduce the reciprocal fusion, AF4-MLL, alongside MLL-AF4 to produce a leukaemia mouse model for drug research to improve treatments.