Nicola Potter

The Evolution and Diversification of Pre-leukaemic Clones in a Natural Model of Acute Lymphoblastic Leukaemia

We are interested in the development and evolution of the most common pre-B cell paediatric acute lymphoblastic leukaemia (ALL). We wish to study the similarities and differences in the mutations and sub-clones that develop in identical twins that share a genetically identical pre-leukaemic clone in order to expand our understanding of the development and pathogeneisis of ALL in children.