Posts found in:
Grantees

Targeting NEDD8 protein conjugation: a novel therapeutic strategy for acute lymphoblastic leukemia (ALL). Acute lymphoblastic leukemia (ALL) is the main cause of cancer related death in children. We have access to a brand new drug that kills these leukemia cells very effectively in the laboratory. We want to study this drug in detail and test […]

Microenvironment and Flt3 Signaling in MLL Leukemia Dr. Mulloy’s lab has recently shown that human blood stem cells can be induced to make leukemia upon introduction of a leukemia oncogene into these cells. This is one of the first models that use human cells rather than mouse cells to produce leukemia. This is a significant […]

Nonablative Allogenic Blood Stem Cell Transplantation for Patients with Indolent Lymphoid Malignancies Chronic lymphocytic leukemia (CLL) is a relatively slowly progressing form of leukemia affecting specialized white blood cells known as lymphocytes. CLL mainly affects older people. One of the most effective treatments for some leukemias, including CLL, is the use of allogenic transplants, in […]

Systematic, High-Throughput Developmental Therapeutics in High-Risk ALL Tragically, many adult and pediatric leukemia patients still succumb to their disease despite intensive combination chemotherapy, stem cell transplantation and improved supportive care. Failure of current treatments to eradicate all traces of disease in leukemia patients ultimately leads to clinical relapse with drug-resistant leukemic cells. By using leukemic […]

Tumor Antigen Receptor Vaccines for Active Immunotherapy of T Cell Malignancies One of the most promising areas of cancer research is the use of immunotherapies-therapies that capitalize on the body’s own immune defenses. An important avenue of immunotherapy research is the use of vaccines to stimulate the immune system to mount its own attack against […]

Evaluating the Effectiveness of an Integrative Approach to the Treatment of Lymphoma and Leukemia Utilizing a Comprehensive Retrospective and Prospective Study Design Integrative Medicine is the application of additional approaches to mainstream conventional care in an integrated fashion. These approaches may include nutritional therapy, exercise, herbal medicine, spiritual healing, vitamin therapy, acupuncture, meditation, massage, and […]

Improving the Efficiency of Alkylation Anticancer Chemotherapies Alkylating agents are extensively used against a number of malignancies such as lymphoma, brain tumors, melanoma and Hodgkin’s disease. These agents kill tumor cells by damaging their DNA. However, repair of the DNA damage induced by these alkylating agents by human DNA repair proteins, especially the human AGT […]

The Role of EGR in establishing a malignant epigenetic program of therapy resistance in CLL Modification of gene structure constitutes a fundamental way healthy cells are reprogrammed into leukemia and gain therapeutic resistance. We will uncover how modifications associated with aggressive disease and relapse are created by reengineering normal cells. This will further our knowledge […]

Role of Epstein-Barr virus RNAs in the Pathogenesis of Virus-associated Lymphoid Tumors Epstein-Barr virus (EBV) infections are associated with a number of types of human cancer, including Burkitt lymphoma, nasopharyngeal carcinoma, and Hodgkin’s lymphoma. EBV carries a number of viral genes whose products are known to result in increased cell growth and/or decreased cell death, […]

Ex Vivo expansion of hematopoietic stem cells for cord blood and allogeneic transplantations The ability to grow blood stem cells (HSCs) in culture would greatly improve the patient outcome in transplantation, and make cord blood to be useful for adult applications. We have identified several new growth factors, and established a very potent cell culture […]

Study Energy Sensing Signaling in Leukemia Stem Cells and Leukemia Development