Scientists have revealed how to modify CRISPR’s basic architecture to extend its reach beyond the genome and into the epigenome – proteins and small molecules that latch onto DNA and control when and where genes are switched on or off. Researchers at University of California San Francisco (UCSF) and the Whitehead Institute, both US, developed the […]
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When researchers from Penn Medicine (including two of our grantees, Dr. Saar Gill and Dr. Marco Ruella!) found that many patients with B-cell acute lymphoblastic leukemia (ALL) treated with the investigational chimeric antigen receptor (CAR) T cell therapy targeting the CD22 antigen didn’t respond, they went back to the drawing board to determine why. They […]
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More details about the study from Gabrielle’s Angels grantee Dr. Etan Orgel! The study found that kids who ate healthier, slightly cut their calorie intake, and burned a bit more energy through exercise wound up with a lot fewer cancer cells lingering in their bodies following their first month of chemo, compared with an earlier […]
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(left: Dr. Steven Mittelman, right: Dr. Etan Orgel) New research published today in the journal Blood Advances is the first to show that restricting calories, reducing fat and sugar intake, and increasing physical activity may boost the effectiveness of chemotherapy for older children and adolescents with leukemia. This intervention, which improved chemotherapy outcomes for children […]
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