Congratulations to Gabrielle’s Angels grantees Dr. Ann Mullally and Dr. Shannon Elf for their recent publication in September’s issue of Blood.  Read the full paper here: “Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs”  Abstract Calreticulin (CALR) mutations are frequent, disease-initiating events in myeloproliferative neoplasms (MPNs). Although the biological mechanism by […]

Up to three quarters of patients receiving cancer chemotherapy suffer from “chemo brain” — a long-term side effect that makes it harder to remember things, maintain attention, and learn new information. When it strikes children, whose brains are still developing, their schoolwork and self-esteem may suffer. In a study published in the journal Neuron on September […]

Acute myeloid leukemia, or AML, is the most common acute blood cancer in adults — and one of the most difficult to treat. Scientists at Oregon Health & Science University have discovered a potential new target for stopping it: a gene that, when active, predicts worse chances of survival.

  On May 24th, 2022 we hosted our 11th annual Medical Research Symposium at Feinstein’s/54 Below in New York City. We hosted researchers both past and present…some we funded as far back as 2000 and some as recently as 2021! It was a wonderful day of presentations, networking, and collaboration. Thank you to our sponsor […]

Researchers at the University of North Carolina at Chapel Hill and the UNC Lineberger Comprehensive Cancer Center have uncovered a new role of a chromatin-modulatory enzyme, termed EZH2, during cancer development. They then developed a new therapeutic approach with a potent small-molecule inhibitor of this enzyme. Gabrielle’s Angels supported this work with a grant to […]

Congratulations to Gabrielle’s Angel Foundation grantee Dr. Shan Zha for being elected to the American Society for Clinical Investigation. “Shan’s work is simply inspiring and is transforming the understanding of DNA repair and how we might utilize that understanding to develop new therapies,” says Jordan Orange, MD, PhD, the Reuben S. Carpentier Professor of Pediatrics and chair of the […]

Gabrielle’s Angels grantee Dr. Ari Melnick of Weill Cornell and his team have recently discovered that aggressive and relatively common lymphomas called diffuse large B cell lymphomas have a critical metabolic vulnerability that can be exploited to trick these cancers into starving themselves. This is a huge breakthrough with many possibilities for future therapeutic applications!  […]

An immunotherapy harnessing the immune system’s “natural killer” cells has proven effective in treating acute myeloid leukemia (AML) in some adults whose cancers return. Now, researchers at Washington University School of Medicine in St. Louis have shown, in a small clinical trial, that the same natural killer cells also can help some children and young […]

Clockwise from top left: Andrew Intlekofer, MSKCC; Shannon Elf*, University of Chicago, Nathan Singh, Washington University St. Louis; Yibin Yang*, Fox Chase Cancer Center; Brian Dalton, Johns Hopkins University; Jamie Berta Spangler; Johns Hopkins University *Mark Foundation for Cancer Research Fellows – these grants will be fully funded by the Mark Foundation The Foundation’s Medical […]

A new study from the lab of longtime Gabrielle’s Angel Foundation Medical Advisory Board member Dr. John DiPersio and Gabrielle’s Angels grantee Dr. Stephen Persaud has revealed a new technique that may lead to safer stem cell transplants. The researchers at Washington University School of Medicine in St. Louis have developed a method of stem […]

Congratulations to Gabrielle’s Angels grantee Dr. Cigall Kadoch from Dana-Farber Cancer Institute for receiving the incredibly prestigious Howard Hughes Medical Institute (HHMI) Investigators Award! Dr. Kadoch will receive roughly $9 million over a seven-year term, which is renewable pending a successful scientific review. HHMI selected the new Investigators from more than 800 eligible applicants. To […]

The Mark Foundation for Cancer Research has partnered with the Gabrielle’s Angel Foundation for Cancer Research to fully support two of its Medical Research Awardees. The awardees, Dr. Shannon Elf from the University of Chicago, and Dr. Yibin Yang from Fox Chase Cancer Center were announced at the Angel Foundation’s 25th Angel Ball on August […]