Monthly Archives:
January 2025

Scientists and Doctors Reveal How Genes are Mapping Cures for Cancer

Scientists and Doctors Reveal How Genes are Mapping Cures for Cancer

Published: Jan 24, 2025   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

A recently published article in Newsweek discusses the groundbreaking advancements in genetic sequencing that are transforming cancer treatment. It highlights how technologies like whole genome sequencing (WGS) are enabling doctors to identify genetic mutations in tumors and personalize treatments for patients, including those with rare or difficult-to-treat cancers. One key example is the case of […]

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Dr Ruella on Improving Access to CAR T-Cell Therapy for Minority Populations in Multiple Myeloma

Dr Ruella on Improving Access to CAR T-Cell Therapy for Minority Populations in Multiple Myeloma

Published: Jan 17, 2025   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

Marco Ruella, MD, Gabrielle’s Angels grantee in 2014 and 2017 (Medical Advisory Board discretionary funding) and 2019 (Medical Research Award), assistant professor, medicine (hematology-oncology), Perelman School of Medicine; scientific director, Lymphoma Program, the Hospital of the University of Pennsylvania, discusses the implications of findings from a retrospective study evaluating access to and outcomes with commercial […]

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Drug in breast cancer trials shows potential for treating blood cancers

Drug in breast cancer trials shows potential for treating blood cancers

Published: Jan 16, 2025   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

Two new studies led by researchers at Washington University School of Medicine in St. Louis have identified a possible way to block the progression of several forms of blood cancer using a drug already in clinical trials against breast cancer. The studies – both conducted in patient samples and animal models – found that inhibiting […]

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RSK1 is an exploitable dependency in myeloproliferative neoplasms and secondary acute myeloid leukemia

RSK1 is an exploitable dependency in myeloproliferative neoplasms and secondary acute myeloid leukemia

Published: Jan 16, 2025   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

Gabrielle’s Angel Foundation grantee Grant Challen, PhD (MRA recipient in 2016 and The Mark Foundation for Cancer Research Collaborative Grant Recipient from 2023) from Washington University in St. Louis is one of the authors of a new paper published in Nature on January 16, 2025 examining the role of RSK1 in myeloproliferative neoplasms and secondary […]

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FDA approves revumenib, a menin inhibitor, for relapsed or refractory acute leukemia with a KMT2A translocation

FDA approves revumenib, a menin inhibitor, for relapsed or refractory acute leukemia with a KMT2A translocation

Published: Jan 15, 2025   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

Big news from Dana-Farber Cancer Institute regarding the FDA approval of revumenib for the treatment of relapsed acute leukemia! Gabrielle’s Angel Foundation funded Scott Armstrong, MD, PhD back in 2007 during the preliminary research of this project. These early efforts to understand how the cell makes use of menin, to explorations of the cell machinery […]

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Surprising findings about blood cell mutations bode well for transplant recipients

Surprising findings about blood cell mutations bode well for transplant recipients

Published: Jan 15, 2025   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

After an allogeneic stem cell transplant, a recipient’s body faces a daunting task: rebuilding the person’s blood-forming and immune systems from the ground up from a relatively small number of “seed” cells obtained from their donor. To achieve this, the donated cells must replicate again and again — and again.  It’s a cycle that might put […]

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Unraveling the Menin Mystery to Halt Cancer Growth

Unraveling the Menin Mystery to Halt Cancer Growth

Published: Jan 15, 2025   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

Exciting news out of Dana-Farber on a  the development of new menin-targeting agents that showed promise in clinical trials involving adults with acute myeloid leukemia (AML), one of the hardest-to-treat forms of leukemia. Scott Armstrong, MD, PhD, Gabrielle’s Angel Foundation Medical Research Award recipient in 2007 and current senior vice president for drug discovery and chief […]

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