Monthly Archives:
September 2022

NIH initiative to systematically investigate and establish function of every human gene

NIH initiative to systematically investigate and establish function of every human gene

Published: Sep 29, 2022   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

The National Institutes of Health is launching a program to better understand the function of every human gene and generate a catalog of the molecular and cellular consequences of inactivating each gene. The Molecular Phenotypes of Null Alleles in Cells (MorPhiC) program, managed by the National Human Genome Research Institute, aims to systematically investigate the […]

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New Grantees Announced

New Grantees Announced

Published: Sep 29, 2022   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

In June, Gabrielle’s Angel Foundation’s Medical Advisory Board selected 16 talented early career scientists to receive funding for a total of $1.8M in grants! Awards ranged from $25,000 – $225,000. We are delighted to welcome these brilliant investigators to our Gabrielle’s Angels family! Stay tuned for spotlights on each grantee and their work throughout the rest of the year. ** Special […]

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Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs

Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs

Published: Sep 20, 2022   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

Congratulations to Gabrielle’s Angels grantees Dr. Ann Mullally and Dr. Shannon Elf for their recent publication in September’s issue of Blood.  Read the full paper here: “Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs”  Abstract Calreticulin (CALR) mutations are frequent, disease-initiating events in myeloproliferative neoplasms (MPNs). Although the biological mechanism by […]

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Preventing ‘chemo brain’ with antioxidants targeting spinal fluid

Preventing ‘chemo brain’ with antioxidants targeting spinal fluid

Published: Sep 15, 2022   |   Author: Michele Keene   |   Category: Medical Updates   |   No Comments

Up to three quarters of patients receiving cancer chemotherapy suffer from “chemo brain” — a long-term side effect that makes it harder to remember things, maintain attention, and learn new information. When it strikes children, whose brains are still developing, their schoolwork and self-esteem may suffer. In a study published in the journal Neuron on September […]

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