Research Updates

Gabrielle’s Angel Foundation grantee Jaebok Choi recently published a paper in Molecules. This study tested a new experimental drug called BI-5756 in laboratory and mouse models of bone marrow transplantation. The researchers found that BI-5756 helps calm harmful immune reactions by increasing the number of “regulatory” immune cells that act as natural brakes on inflammation, while still allowing the immune system to attack cancer cells. In mice, treatment with BI-5756 reduced the severity of graft-versus-host disease, a serious and often life-threatening complication of bone marrow transplants, and improved survival and immune recovery. Importantly, the drug did this without weakening the beneficial anti-cancer effects of the transplant, highlighting its promise as a safer way to protect patients while preserving the treatment’s cancer-fighting power. Read the full paper here: https://gabriellesangels.org/wp-content/uploads/molecules_30_03517-1.pdf