Vu Ngo, PhD

Targeting Cyclin D1 and the DNA Damage Response in Mantle Cell Lymphoma

Mantle cell lymphoma (MCL) is rarely curable. Its hallmark is overexpression of the cell cycle regulatory protein cyclin-D1. We uncovered an unexpected role of cyclin-D1 in maintaining MCL genome integrity. We will investigate whether targeting cyclin-D1 simultaneously with proteins that guard against DNA damage will be effective at eliminating MCL.