Targeting Cyclin D1 and the DNA Damage Response in Mantle Cell Lymphoma
Mantle cell lymphoma (MCL) is rarely curable. Its hallmark is overexpression of the cell cycle regulatory protein cyclin-D1. We uncovered an unexpected role of cyclin-D1 in maintaining MCL genome integrity. We will investigate whether targeting cyclin-D1 simultaneously with proteins that guard against DNA damage will be effective at eliminating MCL.