DR. Mukherjee has been dissecting the roles of Yes-1, MIIt3 and Ctnnd1 in leukemia stem cell quiescence.
Hematopoietic stem cells are maintained in deep quiescence in the bone marrow. A fundamental feature of leukemias is the disruption of this quiescence, resulting in unchecked proliferation. Our laboratory has used a novel high-throughput screen to identify 3 candidate genes that regulate HSCs quiescence and are dysregulated in leukemias. Here, we will interrogate the roles of these genes – Yes1, Mllt3 and Ctnnd1 – in leukemia stem cell biology. Furthermore, we will determine if these genes are therapeutically amenable in human leukemia models. Using a longitudinal repository, we will query the prognostic and diagnostic roles of these genes in AML and MDS.