Panagiotis Ntziachristos, PhD

Post-translational regulation of splicing as a pro-oncogenic mechanism in high-risk T cell leukemia

Chemotherapy for acute lymphoblastic leukemia entails burdensome side-effects, a risk of second cancers and associated resistance. We have identified a mechanism that controls how genes leading to leukemia behave and we aim to exploit this knowledge in order to identify new treatment targets for patients in 3-5 years.