Jennifer Rhodes, PhD

In Vivo Regulation of Myeloid Cell Development and Leukemia

The Rhodes laboratory is using the power of zebrafish genetics to inform on how gene mutation or abnormal activation can affect myeloid cell development and contribute to acute myelogenous leukemia (AML). They have shown that the development of zebrafish myeloid cells is surprisingly similar to humans and discoveries made in this animal model will advance our understanding of human processes. The studies supported by Gabrielle’s Angel Foundation are likely to provide new insights into the myeloid cell biology and transformation, and generate animal models or gene targets that can be used to advance current diagnostic or therapeutic options for AML.