Jaebok Choi

Project Title: Therapeutic use of HDL to enhance the anti-leukemia effects of allo-HCT while preventing GvHD

Project Description: Clinical goal of bone marrow transplantation (BMT) is to enhance anti-leukemia effects of BMT while preventing its major side effect, graft-versus-host disease (GvHD). We have identified gene products that are modulated by HDL, the good cholesterol, as therapeutic targets. Thus, we will determine if boosting HDL can achieve this goal.