Dr. Zuzana Tothova

The role of inflammation during STAG-2 mutant MDS and AML initiation and progression

Although we know that cohesin mutations cause myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), we currently cannot target these mutations in a specific manner. My project will identify unique vulnerabilities in cohesin-mutant MDS and AML with the goal to develop less toxic more effective treatments for these blood cancers.