Dr. Shannon Elf

Title of Grant:       Dissecting the role of the unfolded protein response in type 1 CALRmutated myelofibrosis

 Description: The experiments proposed will help to answer why, among the two types of CALR mutations found in MPN patients, only one type causes myelofibrosis, the most deadly and difficult to treat disease among the three MPN types. This in turn will help us uncover new therapeutic options for CALR-mutated myelofibrosis.

*Mark Foundation Fellow – grant fully funded by the Mark Foundation for Cancer Research