Dr. Sahand Hormoz

“Reconstructing the differentiation dynamics and genealogy of cancer cells
in individual patients with myeloproliferative neoplasms using single-cell
sequencing”

In a type of blood cancer called myeloproliferative neoplasm, the same genetic alteration results in drastically different forms of the disease in different patients. To understand this discrepancy, we will measure the molecular profile of individual cells obtained from patients and reconstruct the genealogical history of the cancer cells.