Ben A. Croker, PhD

Gene editing in ALL to promote immunomodulatory forms of lytic cell death

Cell death removes damaged, pre-malignant, and infected cells. The study of apoptosis has yielded significant insight into the formation and maintenance of leukemia cells: many chemotherapeutics activate apoptotic cell death. We will harness a novel type of inflammatory lytic cell death to promote immunity to T-cell leukemia.