Dr. Aaron Viny, MD, MS

Columbia University - 2025

Investigating chromatin biomarkers for therapeutic sensitivity to Menin inhibition in myeloid malignancies

Cellular DNA is structured as “open” or “closed” chromatin fibers which influences whether genes can be activated/de-activated. Chromatin structure is markedly perturbed in myelodysplastic syndrome and acute myeloid leukemia. This translational proposal tests the hypothesis that “open-ness” of MEIS1 target genes is a biomarker of clinical sensitivity to Menin inhibition.