Dr. Pengda Liu

University of North Carolina School of Medicine - 2019

“Targeting the Innate Immunity-Independent Function of STING in treating AML”

This proposal is to test if inhibiting a deubiquitinase named OTUD7B retards AML growth. We found that AML growth is controlled by an immunity sensor STING through activating an oncogenic kinase called mTOR. This process is facilitated by OTUD7B. Thus, inhibiting OTUD7B suppresses STING-mediated mTOR activation and subsequent AML growth