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The Institute of Cancer Research, London
Genetic Complexity of Quiescent Leukaemic Stem Cells
Childhood acute lymphoblastic leukaemia (ALL) patients respond initially well to chemotherapy, but some relapse due to the proliferation of treatment-resistant dormant cells. We have demonstrated that leukaemia patients have different sub-clones, so no we aim to investigate which of these sub-clones contains dormant cells responsible for subsequent relapses.